› 1c3d

X-ray diffraction
1.8Å resolution

X-RAY CRYSTAL STRUCTURE OF C3D: A C3 FRAGMENT AND LIGAND FOR COMPLEMENT RECEPTOR 2

Released:
DOI: 10.2210/pdb1c3d/pdb
PDB entry 1c3d coloured by chain, front view.
PDB entry 1c3d coloured by chain, side view.
PDB entry 1c3d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2.
Nagar B, Jones RG, Diefenbach RJ, Isenman DE, Rini JM
Science 280 1277-81 (1998)
PMID: 9596584

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-524565 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement C3d fragment Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 32.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01024 (Residues: 995-1287; Coverage: 18%)
Gene names: C3, CPAMD1
Sequence domains: A-macroglobulin TED domain
Structure domains: Glycosyltransferase

Ligands and Environments

1 bound ligand:
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P212121
Unit cell:
a: 60.82Å b: 64.378Å c: 87.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.188 0.23
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

22 review citations

Complement and its role in innate and adaptive immune responses.
Dunkelberger et al. (2010)
21 more

37 mentions without citation

Novel mechanisms and functions of complement.
Hajishengallis et al. (2017)
36 more