› 1d1z

X-ray diffraction
1.4Å resolution

CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP

Released:
DOI: 10.2210/pdb1d1z/pdb
PDB entry 1d1z coloured by chain, front view.
PDB entry 1d1z coloured by chain, side view.
PDB entry 1d1z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ
Mol Cell 4 555-61 (1999)
PMID: 10549287

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-521184 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH2 domain-containing protein 1A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 104 amino acids
Theoretical weight: 11.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60880 (Residues: 1-104; Coverage: 81%)
Gene names: DSHP, SAP, SH2D1A
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P1
Unit cell:
a: 32.48Å b: 62.27Å c: 65.09Å
α: 65.71° β: 78.67° γ: 89.66°
R-values:
R R work R free
0.147 0.139 0.187
Expression system: Escherichia coli

Quick links

Citations

46 review citations

Structure and regulation of Src family kinases.
Boggon et al. (2004)
45 more

6 mentions without citation

Characterization of the fast dynamics of protein amino acid side chains using NMR relaxation in solution.
Igumenova et al. (2006)
5 more