› 1ddt

X-ray diffraction
2Å resolution

THE REFINED STRUCTURE OF DIMERIC DIPHTHERIA TOXIN AT 2.0 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1ddt/pdb
PDB entry 1ddt coloured by chain, front view.
PDB entry 1ddt coloured by chain, side view.
PDB entry 1ddt coloured by chain, top view.
Source organism: Corynephage beta
Primary publication:
Refined structure of dimeric diphtheria toxin at 2.0 A resolution.
Bennett MJ, Choe S, Eisenberg D
Protein Sci 3 1444-63 (1994)
PMID: 7833807

Function and Biology Details

Reaction catalysed: 
NAD(+) + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132743 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Diphtheria toxin Chain: A
Molecule details ›
Chain: A
Length: 535 amino acids
Theoretical weight: 58.41 KDa
Source organism: Corynephage beta
Expression system: Not provided
UniProt:
  • Canonical: P00588 (Residues: 33-567; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand APU 1 x APU
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 105.64Å b: 92.56Å c: 65.58Å
α: 90° β: 94.6° γ: 90°
R-values:
R R work R free
0.195 0.195 not available
Expression system: Not provided

Quick links

Citations

21 review citations

3D domain swapping: a mechanism for oligomer assembly.
Bennett et al. (1995)
20 more

32 mentions without citation

ADP-ribosylation systems in bacteria and viruses.
Mikolčević et al. (2021)
31 more