› 1ddw

X-ray diffraction
1.7Å resolution

HOMER EVH1 DOMAIN UNLIGANDED

Released:
DOI: 10.2210/pdb1ddw/pdb
PDB entry 1ddw coloured by chain, front view.
PDB entry 1ddw coloured by chain, side view.
PDB entry 1ddw coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ
Neuron 26 143-54 (2000)
PMID: 10798399

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195545 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homer protein homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.83 KDa
Source organism: Rattus norvegicus
Expression system: Bacteria
UniProt:
  • Canonical: Q9Z214 (Residues: 1-120; Coverage: 33%)
Gene names: Homer, Homer1, Vesl
Sequence domains: WH1 domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P3221
Unit cell:
a: 49.94Å b: 49.94Å c: 80.91Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.245 0.245 0.285
Expression system: Bacteria

Quick links

Citations

36 review citations

Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Niswender et al. (2010)
35 more

4 mentions without citation

Diversity of polyproline recognition by EVH1 domains.
Peterson et al. (2009)
3 more