› 1dxw

Solution NMR

structure of hetero complex of non structural protein (NS) of hepatitis C virus (HCV) and synthetic peptidic compound

Released:
DOI: 10.2210/pdb1dxw/pdb
PDB entry 1dxw coloured by chain, ensemble of 20 models, front view.
PDB entry 1dxw coloured by chain, ensemble of 20 models, side view.
PDB entry 1dxw coloured by chain, ensemble of 20 models, top view.
Source organism: Hepacivirus hominis
Primary publication:
Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain.
Barbato G, Cicero DO, Cordier F, Narjes F, Gerlach B, Sambucini S, Grzesiek S, Matassa VG, De Francesco R, Bazzo R
EMBO J 19 1195-206 (2000)
PMID: 10716920

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185857 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase S29 domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 186 amino acids
Theoretical weight: 19.63 KDa
Source organism: Hepacivirus hominis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8QW30 (Residues: 1-180; Coverage: 100%)
Sequence domains: Hepatitis C virus NS3 protease
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 2ZF 1 x 2ZF
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 13%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Recent advances in the molecular biology of hepatitis C virus.
Rosenberg S. (2001)
2 more

1 mention without citation

Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain.
Barbato et al. (2000)