› 1ecz

X-ray diffraction
2.68Å resolution

PROTEASE INHIBITOR ECOTIN

Released:
DOI: 10.2210/pdb1ecz/pdb
PDB entry 1ecz coloured by chain, front view.
PDB entry 1ecz coloured by chain, side view.
PDB entry 1ecz coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Crystal structure analyses of uncomplexed ecotin in two crystal forms: implications for its function and stability.
Shin DH, Song HK, Seong IS, Lee CS, Chung CH, Suh SW
Protein Sci 5 2236-47 (1996)
PMID: 8931142

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-540574 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ecotin Chains: A, B
Molecule details ›
Chains: A, B
Length: 142 amino acids
Theoretical weight: 16.12 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P23827 (Residues: 21-162; Coverage: 100%)
Gene names: JW2197, b2209, eco, eti
Sequence domains: Ecotin
Structure domains: Ecotin

Ligands and Environments

1 bound ligand:
Ligand BOG 21 x BOG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 39.22Å b: 84.86Å c: 98.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.309
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function.
Kantyka et al. (2010)
1 more

8 mentions without citation

Designed Metal-ATCUN Derivatives: Redox- and Non-redox-Based Applications Relevant for Chemistry, Biology, and Medicine.
Maiti et al. (2020)
7 more