› 1f9f

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAIN

Released:
DOI: 10.2210/pdb1f9f/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1f9f coloured by chain, front view.
PDB entry 1f9f coloured by chain, side view.
PDB entry 1f9f coloured by chain, top view.
Source organism: Human papillomavirus type 18
Primary publication:
The structural basis of DNA target discrimination by papillomavirus E2 proteins.
Kim SS, Tam JK, Wang AF, Hegde RS
J Biol Chem 275 31245-54 (2000)
PMID: 10906136

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139233 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulatory protein E2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 83 amino acids
Theoretical weight: 9.59 KDa
Source organism: Human papillomavirus type 18
Expression system: Escherichia coli
UniProt:
  • Canonical: P06790 (Residues: 287-365; Coverage: 22%)
Gene name: E2
Sequence domains: E2 (early) protein, C terminal
Structure domains: Alpha-Beta Plaits

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 41.5Å b: 46.8Å c: 161.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.294
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Origins of specificity in protein-DNA recognition.
Rohs et al. (2010)
8 more

9 mentions without citation

Evolutionary and biophysical relationships among the papillomavirus E2 proteins.
Blakaj et al. (2009)
8 more