› 1fc2

X-ray diffraction
2.8Å resolution

Crystallographic Refinement and Atomic Models of a Human FC Fragment and its Complex with Fragment B of Protein A from Staphylococcus Aureus at 2.9-and 2.8-Angstroms Resolution

Released:
DOI: 10.2210/pdb1fc2/pdb
PDB entry 1fc2 coloured by chain, front view.
PDB entry 1fc2 coloured by chain, side view.
PDB entry 1fc2 coloured by chain, top view.
Source organisms:
Primary publication:
Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.
Deisenhofer J
Biochemistry 20 2361-70 (1981)
PMID: 7236608

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-525489 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin G-binding protein A Chain: C
Molecule details ›
Chain: C
Length: 58 amino acids
Theoretical weight: 6.61 KDa
Source organism: Staphylococcus aureus subsp. aureus NCTC 8325
Expression system: Not provided
UniProt:
  • Canonical: P38507 (Residues: 212-269; Coverage: 12%)
Gene name: spa
Sequence domains: B domain
Structure domains: Immunoglobulin FC, subunit C
Immunoglobulin heavy constant gamma 1 Chain: D
Molecule details ›
Chain: D
Length: 224 amino acids
Theoretical weight: 25.24 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01857 (Residues: 106-328; Coverage: 56%)
  • Best match: P01857-1 (Residues: 106-329)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, GAL, FUC
Carbohydrate polymer
1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 70.6Å b: 70.6Å c: 147.4Å
α: 90° β: 90° γ: 120°
Expression system: Not provided

Quick links

Citations

154 review citations

Fcgamma receptors as regulators of immune responses.
Nimmerjahn et al. (2008)
153 more

78 mentions without citation

Fc-Binding Ligands of Immunoglobulin G: An Overview of High Affinity Proteins and Peptides.
Choe et al. (2016)
77 more