› 1ft8

X-ray diffraction
3.15Å resolution

CRYSTAL STRUCTURE OF THE RNA-BINDING DOMAIN OF THE MRNA EXPORT FACTOR TAP

Released:
DOI: 10.2210/pdb1ft8/pdb
PDB entry 1ft8 coloured by chain, front view.
PDB entry 1ft8 coloured by chain, side view.
PDB entry 1ft8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain.
Liker E, Fernandez E, Izaurralde E, Conti E
EMBO J 19 5587-98 (2000)
PMID: 11060011

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-577359 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear RNA export factor 1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 271 amino acids
Theoretical weight: 30.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBU9 (Residues: 102-372; Coverage: 44%)
Gene names: NXF1, TAP
Sequence domains: Tap, RNA-binding
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P41212
Unit cell:
a: 139.918Å b: 139.918Å c: 206.703Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.303 0.303 0.303
Expression system: Escherichia coli

Quick links

Citations

16 review citations

The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression.
Maris et al. (2005)
15 more

6 mentions without citation

Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors.
Matsushima et al. (2007)
5 more