› 1fyw

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2

Released:
DOI: 10.2210/pdb1fyw/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1fyw coloured by chain, front view.
PDB entry 1fyw coloured by chain, side view.
PDB entry 1fyw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L
Nature 408 111-5 (2000)
PMID: 11081518

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-130043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 149 amino acids
Theoretical weight: 18.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60603 (Residues: 636-784; Coverage: 20%)
Gene names: TIL4, TLR2
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
2 modified residues:
Ligand CAS 4 x CAS
Ligand MSE 3 x MSE

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P6222
Unit cell:
a: 121.2Å b: 121.2Å c: 91.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.26 0.244 0.274
Expression system: Escherichia coli

Quick links

Citations

99 review citations

Toll-like receptor signalling.
Akira et al. (2004)
98 more

44 mentions without citation

Recognition of lipopolysaccharide pattern by TLR4 complexes.
Park et al. (2013)
43 more