› 1hml

X-ray diffraction
1.7Å resolution

ALPHA_LACTALBUMIN POSSESSES A DISTINCT ZINC BINDING SITE

Released:
DOI: 10.2210/pdb1hml/pdb
PDB entry 1hml coloured by chain, front view.
PDB entry 1hml coloured by chain, side view.
PDB entry 1hml coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Alpha-lactalbumin possesses a distinct zinc binding site.
Ren J, Stuart DI, Acharya KR
J Biol Chem 268 19292-8 (1993)
PMID: 8366079

Function and Biology Details

Reaction catalysed: 
UDP-alpha-D-galactose + D-glucose = UDP + lactose
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132931 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-lactalbumin Chain: A
Molecule details ›
Chain: A
Length: 142 amino acids
Theoretical weight: 16.24 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00709 (Residues: 1-142; Coverage: 100%)
Gene names: LALBA, LYZL7
Sequence domains: C-type lysozyme/alpha-lactalbumin family
Structure domains: Lysozyme

Ligands and Environments

3 bound ligands:
Ligand CA 1 x CA
Ligand ZN 1 x ZN
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 35.6Å b: 69.7Å c: 46.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.165 not available
Expression system: Not provided

Quick links

Citations

9 review citations

Nutritional and physiologic significance of human milk proteins.
Lönnerdal B. (2003)
8 more

12 mentions without citation

Protein unfolding: rigidity lost.
Rader et al. (2002)
11 more