› 1ipb

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139166 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 4E Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06730 (Residues: 1-217; Coverage: 100%)
Gene names: EIF4E, EIF4EL1, EIF4F
Sequence domains: Eukaryotic initiation factor 4E
Structure domains: RNA Cap, Translation Initiation Factor Eif4e

Ligands and Environments

1 bound ligand:
Ligand GTA 1 x GTA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL24XU
Spacegroup: P43
Unit cell:
a: 89.26Å b: 89.26Å c: 38.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.229
Expression system: Escherichia coli

Quick links

Citations

19 review citations

The molecular mechanics of eukaryotic translation.
Kapp et al. (2004)
18 more

9 mentions without citation

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.
Cencic et al. (2011)
8 more