› 1iv5

X-ray diffraction
2.6Å resolution

New Crystal Form of Human CD81 Large Extracellular Loop.

Released:
DOI: 10.2210/pdb1iv5/pdb
PDB entry 1iv5 coloured by chain, front view.
PDB entry 1iv5 coloured by chain, side view.
PDB entry 1iv5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop.
Kitadokoro K, Ponassi M, Galli G, Petracca R, Falugi F, Grandi G, Bolognesi M
Biol Chem 383 1447-52 (2002)
PMID: 12437138

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157955 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD81 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 90 amino acids
Theoretical weight: 9.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60033 (Residues: 113-201; Coverage: 38%)
Gene names: CD81, TAPA1, TSPAN28
Sequence domains: Tetraspanin family
Structure domains: Tetraspanin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL40B2
Spacegroup: P64
Unit cell:
a: 102.052Å b: 102.052Å c: 35.283Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.229 0.282
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain.
Hemler ME. (2003)
8 more

8 mentions without citation

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.
Zimmerman et al. (2016)
7 more