› 1j1c

X-ray diffraction
2.1Å resolution

Binary complex structure of human tau protein kinase I with ADP

Released:
DOI: 10.2210/pdb1j1c/pdb
PDB entry 1j1c coloured by chain, front view.
PDB entry 1j1c coloured by chain, side view.
PDB entry 1j1c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta.
Aoki M, Yokota T, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Ishiguro K, Kohno T, Sugio S, Matsuzaki T
Acta Crystallogr D Biol Crystallogr 60 439-46 (2004)
PMID: 14993667

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 420 amino acids
Theoretical weight: 46.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49841 (Residues: 1-420; Coverage: 100%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand ADP 2 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P212121
Unit cell:
a: 82.9Å b: 86.1Å c: 178.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 0.242
Expression system: Escherichia coli

Quick links

Citations

13 citation in other articles

A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.
Buescher et al. (2010)
12 more

15 mentions without citation

Computer Aided Drug Design Methodologies with Natural Products in the Drug Research Against Alzheimer's Disease.
de Sousa et al. (2022)
14 more