› 1j2e

X-ray diffraction
2.6Å resolution

Crystal structure of Human Dipeptidyl peptidase IV

Released:
DOI: 10.2210/pdb1j2e/pdb
PDB entry 1j2e coloured by chain, front view.
PDB entry 1j2e coloured by chain, side view.
PDB entry 1j2e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold.
Hiramatsu H, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Yamamoto A, Shimizu R
Biochem Biophys Res Commun 302 849-54 (2003)
PMID: 12646248

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 740 amino acids
Theoretical weight: 85.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27487 (Residues: 33-766; Coverage: 96%)
Gene names: ADCP2, CD26, DPP4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 10 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 118.04Å b: 125.92Å c: 136.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.249 0.302
Expression system: Spodoptera frugiperda

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Citations

5 review citations

Molecular physiology and modulation of somatodendritic A-type potassium channels.
Jerng et al. (2004)
4 more

16 mentions without citation

Human cell receptors: potential drug targets to combat COVID-19.
Raghav et al. (2021)
15 more