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Solution NMR

Solution Structure of the Noncompetitive Skeletal Muscle Nicotinic Acetylcholine Receptor Antagonist Psi-conotoxin PIIIE

Released:
DOI: 10.2210/pdb1jlo/pdb
PDB entry 1jlo coloured by chain, ensemble of 13 models, front view.
PDB entry 1jlo coloured by chain, ensemble of 13 models, side view.
PDB entry 1jlo coloured by chain, ensemble of 13 models, top view.
Source organism: Conus purpurascens
Primary publication:
An improved solution structure for psi-conotoxin PiiiE.
Van Wagoner RM, Ireland CM
Biochemistry 42 6347-52 (2003)
PMID: 12767215

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Psi-conotoxin PIIIE Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 2.73 KDa
Source organism: Conus purpurascens
Expression system: Not provided
UniProt:
  • Canonical: P56529 (Residues: 51-73; Coverage: 41%)
Sequence domains: Conotoxin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 3 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry molecular dynamics relaxation matrix distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

3 review citations

Conus venoms: a rich source of novel ion channel-targeted peptides.
Terlau et al. (2004)
2 more

4 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
3 more