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X-ray diffraction
2.4Å resolution

Crystal Structure Analysis of the Anthranilate Phosphoribosyltransferase from Erwinia carotovora (current name, Pectobacterium carotovorum)

Released:
DOI: 10.2210/pdb1kgz/pdb
PDB entry 1kgz coloured by chain, front view.
PDB entry 1kgz coloured by chain, side view.
PDB entry 1kgz coloured by chain, top view.
Source organism: Pectobacterium carotovorum
Primary publication:
The crystal structure of anthranilate phosphoribosyltransferase from the enterobacterium Pectobacterium carotovorum.
Kim C, Xuong NH, Edwards S, Yee MC, Spraggon G, Mills SE
FEBS Lett 523 239-46 (2002)
PMID: 12123839

Function and Biology Details

Reaction catalysed: 
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anthranilate phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 345 amino acids
Theoretical weight: 37.06 KDa
Source organism: Pectobacterium carotovorum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8VP84 (Residues: 1-345; Coverage: 100%)
Gene name: trpD
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand HG 2 x HG
Ligand MN 4 x MN
Ligand PRP 2 x PRP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 77.378Å b: 81.686Å c: 101.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.265
Expression system: Escherichia coli

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Citations

3 review citations

Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.
Hove-Jensen et al. (2017)
2 more

3 mentions without citation

Structure, mechanism and inhibition of anthranilate phosphoribosyltransferase.
Scully et al. (2023)
2 more