1l5g

X-ray diffraction
3.2Å resolution

CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-138436 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Integrin alpha-V Chain: A
Molecule details ›
Chain: A
Length: 957 amino acids
Theoretical weight: 105.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06756 (Residues: 31-987; Coverage: 94%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Structure domains:
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 692 amino acids
Theoretical weight: 76.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P05106 (Residues: 27-718; Coverage: 91%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:
CYCLIC ARG-GLY-ASP PEPTIDE Chain: C
Molecule details ›
Chain: C
Length: 5 amino acids
Theoretical weight: 608 Da

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, NDG
2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 129.79Å b: 129.79Å c: 308.78Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.248 0.248 0.328
Expression system: Spodoptera frugiperda