› 1lui

Solution NMR

NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures

Released:
DOI: 10.2210/pdb1lui/pdb
PDB entry 1lui coloured by chain, ensemble of 20 models, front view.
PDB entry 1lui coloured by chain, ensemble of 20 models, side view.
PDB entry 1lui coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structural characterization of a proline-driven conformational switch within the Itk SH2 domain.
Mallis RJ, Brazin KN, Fulton DB, Andreotti AH
Nat Struct Biol 9 900-5 (2002)
PMID: 12402030

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169911 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ITK/TSK Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 12.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q03526 (Residues: 238-344; Coverage: 17%)
Gene names: Emt, Itk, Tlk, Tsk
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry and simulated annealing
Expression system: Escherichia coli BL21

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Citations

14 review citations

The cyclophilins.
Wang et al. (2005)
13 more

1 mention without citation

Structural and Phylogenetic In Silico Characterization of <i>Vitis vinifera</i> PRR Protein as Potential Target for <i>Plasmopara viticola</i> Infection.
Martínez-Navarro et al. (2024)