› 1mv4

Solution NMR

TM9A251-284: A Peptide Model of the C-Terminus of a Rat Striated Alpha Tropomyosin

Released:
DOI: 10.2210/pdb1mv4/pdb
PDB entry 1mv4 coloured by chain, ensemble of 10 models, front view.
PDB entry 1mv4 coloured by chain, ensemble of 10 models, side view.
PDB entry 1mv4 coloured by chain, ensemble of 10 models, top view.
Source organism: Rattus norvegicus
Primary publication:
The structure of the carboxyl terminus of striated alpha-tropomyosin in solution reveals an unusual parallel arrangement of interacting alpha-helices.
Greenfield NJ, Swapna GV, Huang Y, Palm T, Graboski S, Montelione GT, Hitchcock-DeGregori SE
Biochemistry 42 614-9 (2003)
PMID: 12534273

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138147 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tropomyosin alpha-1 chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 37 amino acids
Theoretical weight: 4.18 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04692 (Residues: 251-284; Coverage: 12%)
Gene names: Alpha-tm, Tpm1, Tpma

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: 1648 CONFORMATIONALLY- RESTRICTING NOE CONSTRAINTS (OUT OF A TOTAL OF 2036 NOE DERIVED DISTANCES) 52 LOOSE DIHEDRAL ANGLE CONSTRAINTS AND 48 BACKBONE INTRA- HELICAL HYDROGEN BOND CONSTRAINTS WERE UTILILIZED.
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Calcium, thin filaments, and the integrative biology of cardiac contractility.
Kobayashi et al. (2005)
2 more

1 mention without citation

Comparing interfacial dynamics in protein-protein complexes: an elastic network approach.
Zen et al. (2010)