› 1niy

Solution NMR

THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-IV BY 2D 1H-NMR

Released:
DOI: 10.2210/pdb1niy/pdb
PDB entry 1niy coloured by chain, ensemble of 20 models, front view.
PDB entry 1niy coloured by chain, ensemble of 20 models, side view.
PDB entry 1niy coloured by chain, ensemble of 20 models, top view.
Source organism: Haplopelma hainanum
Primary publication:
Structure--activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers.
Li D, Xiao Y, Xu X, Xiong X, Lu S, Liu Z, Zhu Q, Wang M, Gu X, Liang S
J Biol Chem 279 37734-40 (2004)
PMID: 15201273

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112436 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-theraphotoxin-Hhn1b 1 Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 4 KDa
Source organism: Haplopelma hainanum
UniProt:
  • Canonical: D2Y232 (Residues: 50-84; Coverage: 54%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

8 review citations

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.
Klint et al. (2012)
7 more

15 mentions without citation

Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels.
Cardoso et al. (2019)
14 more