› 1npl

X-ray diffraction
2Å resolution

MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM DAFFODIL (NARCISSUS PSEUDONARCISSUS) BULBS IN COMPLEX WITH MANNOSE-ALPHA1,3-MANNOSE

Released:
DOI: 10.2210/pdb1npl/pdb
PDB entry 1npl coloured by chain, front view.
PDB entry 1npl coloured by chain, side view.
PDB entry 1npl coloured by chain, top view.
Source organism: Narcissus pseudonarcissus
Primary publication:
Insights into carbohydrate recognition by Narcissus pseudonarcissus lectin: the crystal structure at 2 A resolution in complex with alpha1-3 mannobiose.
Sauerborn MK, Wright LM, Reynolds CD, Grossmann JG, Rizkallah PJ
J Mol Biol 290 185-99 (1999)
PMID: 10388566

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110979 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Mannose-specific lectin Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.21 KDa
Source organism: Narcissus pseudonarcissus
UniProt:
  • Canonical: C0HM45 (Residues: 1-109; Coverage: 100%)
Structure domains: Bulb-type lectin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN
Carbohydrate polymer
1 bound ligand:
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: C222
Unit cell:
a: 73.3Å b: 101.2Å c: 37.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.267

Quick links

Citations

5 review citations

Lectins.
Vijayan et al. (1999)
4 more

6 mentions without citation

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.
Balzarini J. (2007)
5 more