› 1q2j

Solution NMR

Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA

Released:
DOI: 10.2210/pdb1q2j/pdb
PDB entry 1q2j coloured by chain, ensemble of 20 models, front view.
PDB entry 1q2j coloured by chain, ensemble of 20 models, side view.
PDB entry 1q2j coloured by chain, ensemble of 20 models, top view.
Source organism: Conus stercusmuscarum
Primary publication:
Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA.
Keizer DW, West PJ, Lee EF, Yoshikami D, Olivera BM, Bulaj G, Norton RS
J Biol Chem 278 46805-13 (2003)
PMID: 12970353

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157978 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-conotoxin SmIIIA Chain: A
Molecule details ›
Chain: A
Length: 22 amino acids
Theoretical weight: 2.62 KDa
Source organism: Conus stercusmuscarum
Expression system: Not provided
UniProt:
  • Canonical: P60207 (Residues: 7-28; Coverage: 71%)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

14 review citations

Voltage-gated sodium channels and pain pathways.
Wood et al. (2004)
13 more

11 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
10 more