› 1q2n

Solution NMR

REFINED Solution NMR structure of the Z domain of STAPHYLOCOCCAL PROTEIN A

Released:
DOI: 10.2210/pdb1q2n/pdb
PDB entry 1q2n coloured by chain, ensemble of 10 models, front view.
PDB entry 1q2n coloured by chain, ensemble of 10 models, side view.
PDB entry 1q2n coloured by chain, ensemble of 10 models, top view.
Source organism: Staphylococcus aureus
Primary publication:
Validation of helical tilt angles in the solution NMR structure of the Z domain of Staphylococcal protein A by combined analysis of residual dipolar coupling and NOE data.
Zheng D, Aramini JM, Montelione GT
Protein Sci 13 549-54 (2004)
PMID: 14718654

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153667 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin G-binding protein A Chain: A
Molecule details ›
Chain: A
Length: 58 amino acids
Theoretical weight: 6.65 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: P38507 (Residues: 212-269; Coverage: 12%)
Gene name: spa
Sequence domains: B domain
Structure domains: Immunoglobulin FC, subunit C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING WITH RESTRAINED MOLECULAR DYNAMICS, PROTOCAL USED: ANNEAL.INP
Expression system: Escherichia coli

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Citations

2 review citations

Update: affibody molecules for molecular imaging and therapy for cancer.
Orlova et al. (2007)
1 more

25 mentions without citation

In vitro-engineered non-antibody protein therapeutics.
Simeon et al. (2018)
24 more