› 1q40

X-ray diffraction
1.95Å resolution

Crystal structure of the C. albicans Mtr2-Mex67 M domain complex

Released:
DOI: 10.2210/pdb1q40/pdb
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PDB entry 1q40 coloured by chain, front view.
PDB entry 1q40 coloured by chain, side view.
PDB entry 1q40 coloured by chain, top view.
Source organism: Candida albicans
Primary publication:
The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export.
Senay C, Ferrari P, Rocher C, Rieger KJ, Winter J, Platel D, Bourne Y
J Biol Chem 278 48395-403 (2003)
PMID: 14504280

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-160846 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
mRNA transport regulator MTR2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 201 amino acids
Theoretical weight: 22.87 KDa
Source organism: Candida albicans
Expression system: Escherichia coli
UniProt:
  • Canonical: P84148 (Residues: 1-181; Coverage: 100%)
Gene name: MTR2
Sequence domains: Nuclear pore RNA shuttling protein Mtr2
Structure domains: Nuclear Transport Factor 2; Chain: A,
mRNA export factor MEX67 Chains: B, D
Molecule details ›
Chains: B, D
Length: 219 amino acids
Theoretical weight: 25.04 KDa
Source organism: Candida albicans
Expression system: Escherichia coli
UniProt:
  • Canonical: P84149 (Residues: 295-512; Coverage: 35%)
Gene names: CAALFM_CR04050CA, CaO19.488, CaO19.8118, MEX67
Sequence domains: Nuclear RNA export factor, NTF2 domain
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
1 modified residue:
Ligand MSE 24 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P21
Unit cell:
a: 70.414Å b: 54.077Å c: 109.751Å
α: 90° β: 96.12° γ: 90°
R-values:
R R work R free
0.178 0.177 0.219
Expression system: Escherichia coli

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Citations

6 review citations

Flexible gates: dynamic topologies and functions for FG nucleoporins in nucleocytoplasmic transport.
Terry et al. (2009)
5 more

7 mentions without citation

Transcriptome of American oysters, Crassostrea virginica, in response to bacterial challenge: insights into potential mechanisms of disease resistance.
McDowell et al. (2014)
6 more

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