› 1q47

X-ray diffraction
2.8Å resolution

Structure of the Semaphorin 3A Receptor-Binding Module

Released:
DOI: 10.2210/pdb1q47/pdb
PDB entry 1q47 coloured by chain, front view.
PDB entry 1q47 coloured by chain, side view.
PDB entry 1q47 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the semaphorin-3A receptor binding module.
Antipenko A, Himanen JP, van Leyen K, Nardi-Dei V, Lesniak J, Barton WA, Rajashankar KR, Lu M, Hoemme C, Püschel AW, Nikolov DB
Neuron 39 589-98 (2003)
PMID: 12925274

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-517664 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Semaphorin-3A Chains: A, B
Molecule details ›
Chains: A, B
Length: 495 amino acids
Theoretical weight: 56.46 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O08665 (Residues: 26-520; Coverage: 66%)
Gene names: SemD, Sema3a, Semad
Sequence domains: Sema domain
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 8-BM
Spacegroup: C2
Unit cell:
a: 218.791Å b: 59.733Å c: 122.715Å
α: 90° β: 109.007° γ: 90°
R-values:
R R work R free
0.249 not available 0.294
Expression system: Spodoptera frugiperda

Quick links

Citations

43 review citations

Semaphorins command cells to move.
Kruger et al. (2005)
42 more

6 mentions without citation

Structural basis of semaphorin-plexin signalling.
Janssen et al. (2010)
5 more