› 1q8m

X-ray diffraction
2.6Å resolution

Crystal structure of the human myeloid cell activating receptor TREM-1

Released:
DOI: 10.2210/pdb1q8m/pdb
PDB entry 1q8m coloured by chain, front view.
PDB entry 1q8m coloured by chain, side view.
PDB entry 1q8m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human myeloid cell activating receptor TREM-1.
Radaev S, Kattah M, Rostro B, Colonna M, Sun PD
Structure 11 1527-35 (2003)
PMID: 14656437

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-576196 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triggering receptor expressed on myeloid cells 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 14.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NP99 (Residues: 17-134; Coverage: 53%)
Gene name: TREM1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 10 x SO4
Ligand GSH 1 x GSH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 50.315Å b: 128.595Å c: 62.389Å
α: 90° β: 101.69° γ: 90°
R-values:
R R work R free
0.201 0.201 0.251
Expression system: Escherichia coli

Quick links

Citations

17 review citations

The TREM receptor family and signal integration.
Klesney-Tait et al. (2006)
16 more

6 mentions without citation

Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor.
Radaev et al. (2010)
5 more