› 1qty

X-ray diffraction
2.7Å resolution

VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR

Released:
DOI: 10.2210/pdb1qty/pdb
PDB entry 1qty coloured by chain, front view.
PDB entry 1qty coloured by chain, side view.
PDB entry 1qty coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
Starovasnik MA, Christinger HW, Wiesmann C, Champe MA, de Vos AM, Skelton NJ
J Mol Biol 293 531-44 (1999)
PMID: 10543948

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-147430 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N-VEGF Chains: R, S, V, W
Molecule details ›
Chains: R, S, V, W
Length: 102 amino acids
Theoretical weight: 11.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15692 (Residues: 214-315; Coverage: 26%)
Gene names: VEGF, VEGFA
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines
Vascular endothelial growth factor receptor 1 Chains: T, U, X, Y
Molecule details ›
Chains: T, U, X, Y
Length: 101 amino acids
Theoretical weight: 11.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17948 (Residues: 129-229; Coverage: 8%)
Gene names: FLT, FLT1, FRT, VEGFR1
Sequence domains: Vascular endothelial growth factor receptor 1-like, Ig-like domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 124.31Å b: 67.01Å c: 120.84Å
α: 90° β: 118.15° γ: 90°
R-values:
R R work R free
0.233 0.233 0.284
Expression system: Escherichia coli

Quick links

Citations

7 review citations

VEGF-A splicing: the key to anti-angiogenic therapeutics?
Harper et al. (2008)
6 more

8 mentions without citation

Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy.
Shaik et al. (2020)
7 more