› 1ryg

Solution NMR

Three dimensional solution structure of the R29A MUTANT of sodium channels inhibitor HAINANTOXIN-IV by 2D 1H-NMR

Released:
DOI: 10.2210/pdb1ryg/pdb
PDB entry 1ryg coloured by chain, ensemble of 20 models, front view.
PDB entry 1ryg coloured by chain, ensemble of 20 models, side view.
PDB entry 1ryg coloured by chain, ensemble of 20 models, top view.
Source organism: Haplopelma hainanum
Primary publication:
Structure--activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers.
Li D, Xiao Y, Xu X, Xiong X, Lu S, Liu Z, Zhu Q, Wang M, Gu X, Liang S
J Biol Chem 279 37734-40 (2004)
PMID: 15201273

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112436 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-theraphotoxin-Hhn1b 1 Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 3.91 KDa
Source organism: Haplopelma hainanum
Expression system: Not provided
UniProt:
  • Canonical: D2Y232 (Residues: 50-84; Coverage: 54%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

9 review citations

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.
Klint et al. (2012)
8 more

2 mentions without citation

Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities.
Wu et al. (2019)
1 more