› 1t2l

X-ray diffraction
2.8Å resolution

Three Crystal Structures of Human Coactosin-like Protein

Released:
DOI: 10.2210/pdb1t2l/pdb
PDB entry 1t2l coloured by chain, front view.
PDB entry 1t2l coloured by chain, side view.
PDB entry 1t2l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human coactosin-like protein.
Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W
J Mol Biol 344 317-23 (2004)
PMID: 15522287

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171902 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coactosin-like protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 141 amino acids
Theoretical weight: 15.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14019 (Residues: 2-142; Coverage: 99%)
Gene names: CLP, COTL1
Sequence domains: Cofilin/tropomyosin-type actin-binding protein
Structure domains: Severin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: C2
Unit cell:
a: 124.018Å b: 37.033Å c: 60.322Å
α: 90° β: 106.83° γ: 90°
R-values:
R R work R free
0.205 0.197 0.269
Expression system: Escherichia coli BL21(DE3)

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Citations

4 citation in other articles

Mammalian twinfilin sequesters ADP-G-actin and caps filament barbed ends: implications in motility.
Helfer et al. (2006)
3 more