› 1t6o

X-ray diffraction
2Å resolution

Nucleocapsid-binding domain of the measles virus P protein (amino acids 457-507) in complex with amino acids 486-505 of the measles virus N protein

Released:
DOI: 10.2210/pdb1t6o/pdb
PDB entry 1t6o coloured by chain, front view.
PDB entry 1t6o coloured by chain, side view.
PDB entry 1t6o coloured by chain, top view.
Source organism: Measles morbillivirus
Primary publication:
Structural basis for the attachment of a paramyxoviral polymerase to its template.
Kingston RL, Hamel DJ, Gay LS, Dahlquist FW, Matthews BW
Proc Natl Acad Sci U S A 101 8301-6 (2004)
PMID: 15159535

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-162460 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Phosphoprotein Chain: A
Molecule details ›
Chain: A
Length: 51 amino acids
Theoretical weight: 5.89 KDa
Source organism: Measles morbillivirus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q77M42 (Residues: 457-507; Coverage: 10%)
Gene name: P
Structure domains: DNA helicase RuvA subunit, C-terminal domain
linker Chain: L
Molecule details ›
Chain: L
Length: 8 amino acids
Theoretical weight: 595 Da
Nucleoprotein Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.16 KDa
Source organism: Measles morbillivirus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q77M43 (Residues: 486-505; Coverage: 4%)
Gene names: N, NP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 42.226Å b: 42.226Å c: 81.778Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.275
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling.
Uversky et al. (2005)
19 more

25 mentions without citation

Linkers in the structural biology of protein-protein interactions.
Reddy Chichili et al. (2013)
24 more