Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assemblies composition:
Assembly name:
PDBe Complex ID:
PDB-CPX-133173 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain
Molecule details ›
Chains: J, L
Length: 49 amino acids
Theoretical weight: 5.74 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Thrombin light chain
Structure domains: Thrombin light chain domain
Length: 49 amino acids
Theoretical weight: 5.74 KDa
Source organism: Bos taurus
UniProt:
- Canonical:
P00735 (Residues: 318-366; Coverage: 8%)
Sequence domains: Thrombin light chain
Structure domains: Thrombin light chain domain
Thrombin heavy chain
Molecule details ›
Chains: H, K
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P00735 (Residues: 367-625; Coverage: 43%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Thrombin inhibitor rhodniin
Molecule details ›
Chains: R, S
Length: 103 amino acids
Theoretical weight: 11.09 KDa
Source organism: Rhodnius prolixus
Expression system: Escherichia coli
UniProt:
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1
Length: 103 amino acids
Theoretical weight: 11.09 KDa
Source organism: Rhodnius prolixus
Expression system: Escherichia coli
UniProt:
- Canonical: Q06684 (Residues: 1-103; Coverage: 100%)
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Spacegroup:
C2
Expression system: Escherichia coli
