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X-ray diffraction
2.4Å resolution

N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH GLYCOPEPTIDE

Released:
DOI: 10.2210/pdb1url/pdb
PDB entry 1url coloured by chain, front view.
PDB entry 1url coloured by chain, side view.
PDB entry 1url coloured by chain, top view.
Source organisms:
Primary publication:
Complex of sialoadhesin with a glycopeptide ligand.
Bukrinsky JT, St Hilaire PM, Meldal M, Crocker PR, Henriksen A
Biochim Biophys Acta 1702 173-9 (2004)
PMID: 15488769

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-552588 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sialoadhesin Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.2 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q62230 (Residues: 20-137; Coverage: 7%)
Gene names: Sa, Siglec1, Sn
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
ALA-GLY-HIS-THR-TRP-GLY-HIA Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 765 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SIA 1 x SIA
1 modified residue:
Ligand HIA 1 x HIA

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P21212
Unit cell:
a: 42.23Å b: 78.46Å c: 34.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.273
Expression systems:
  • Cricetulus griseus
  • Not provided

Quick links

Citations

6 citation in other articles

A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists.
York et al. (2007)
5 more

4 mentions without citation

Structural basis of myelin-associated glycoprotein adhesion and signalling.
Pronker et al. (2016)
3 more