› 1vpu

Solution NMR

NMR SOLUTION STRUCTURE OF THE HIV-1 VPU CYTOPLASMIC DOMAIN, 9 STRUCTURES

Released:
DOI: 10.2210/pdb1vpu/pdb
PDB entry 1vpu coloured by chain, ensemble of 9 models, front view.
PDB entry 1vpu coloured by chain, ensemble of 9 models, side view.
PDB entry 1vpu coloured by chain, ensemble of 9 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Secondary structure and tertiary fold of the human immunodeficiency virus protein U (Vpu) cytoplasmic domain in solution.
Willbold D, Hoffmann S, Rösch P
Eur J Biochem 245 581-8 (1997)
PMID: 9182993

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Vpu Chain: A
Molecule details ›
Chain: A
Length: 45 amino acids
Theoretical weight: 5.11 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19554 (Residues: 38-81; Coverage: 54%)
Gene name: vpu
Sequence domains: Vpu protein
Structure domains: HIV-1 VPU cytoplasmic domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING, RESTRAINED MOLECULAR DYNAMICS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Viroporins.
Gonzalez et al. (2003)
9 more

10 mentions without citation

Viral channel forming proteins--How to assemble and depolarize lipid membranes in silico.
Fischer et al. (2016)
9 more