› 1y6b

X-ray diffraction
2.1Å resolution

Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor

Released:
DOI: 10.2210/pdb1y6b/pdb
PDB entry 1y6b coloured by chain, front view.
PDB entry 1y6b coloured by chain, side view.
PDB entry 1y6b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
Harris PA, Cheung M, Hunter RN, Brown ML, Veal JM, Nolte RT, Wang L, Liu W, Crosby RM, Johnson JH, Epperly AH, Kumar R, Luttrell DK, Stafford JA
J Med Chem 48 1610-9 (2005)
PMID: 15743202

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 41.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35968 (Residues: 806-1171; Coverage: 27%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand AAX 1 x AAX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 37.544Å b: 94.333Å c: 96.767Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.236
Expression system: Escherichia coli

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Citations

4 review citations

Pazopanib: a multikinase inhibitor with activity in advanced renal cell carcinoma.
Bukowski RM. (2010)
3 more

24 mentions without citation

In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs.
Gagic et al. (2019)
23 more