› 1yyg

X-ray diffraction
1.6Å resolution

Manganese peroxidase complexed with Cd(II) inhibitor

Released:
DOI: 10.2210/pdb1yyg/pdb
PDB entry 1yyg coloured by chain, front view.
PDB entry 1yyg coloured by chain, side view.
PDB entry 1yyg coloured by chain, top view.
Source organism: Phanerodontia chrysosporium
Primary publication:
High-resolution crystal structure of manganese peroxidase: substrate and inhibitor complexes.
Sundaramoorthy M, Youngs HL, Gold MH, Poulos TL
Biochemistry 44 6463-70 (2005)
PMID: 15850380

Function and Biology Details

Reaction catalysed: 
2 Mn(2+) + 2 H(+) + H(2)O(2) = 2 Mn(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169732 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Manganese peroxidase 1 Chain: A
Molecule details ›
Chain: A
Length: 357 amino acids
Theoretical weight: 37.48 KDa
Source organism: Phanerodontia chrysosporium
UniProt:
  • Canonical: Q02567 (Residues: 22-378; Coverage: 100%)
Gene name: MNP1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand MAN 1 x MAN
Ligand CA 3 x CA
Ligand NA 1 x NA
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 160.352Å b: 45.259Å c: 52.714Å
α: 90° β: 97.21° γ: 90°
R-values:
R R work R free
0.165 0.165 0.225

Quick links

Citations

11 review citations

Heme enzyme structure and function.
Poulos TL. (2014)
10 more

1 mention without citation

Food-Grade Expression of Manganese Peroxidases in Recombinant Kluyveromyces lactis and Degradation of Aflatoxin B1 Using Fermentation Supernatants.
Xia et al. (2021)