› 1z0n

X-ray diffraction
1.49Å resolution

the glycogen-binding domain of the AMP-activated protein kinase

Released:
DOI: 10.2210/pdb1z0n/pdb
PDB entry 1z0n coloured by chain, front view.
PDB entry 1z0n coloured by chain, side view.
PDB entry 1z0n coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for glycogen recognition by AMP-activated protein kinase.
Polekhina G, Gupta A, van Denderen BJ, Feil SC, Kemp BE, Stapleton D, Parker MW
Structure 13 1453-62 (2005)
PMID: 16216577

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160402 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
5'-AMP-activated protein kinase subunit beta-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 96 amino acids
Theoretical weight: 10.97 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P80386 (Residues: 68-163; Coverage: 36%)
Gene name: Prkab1
Sequence domains: Glycogen recognition site of AMP-activated protein kinase
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
No bound ligands
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: P1
Unit cell:
a: 43.75Å b: 45.25Å c: 50.6Å
α: 71.9° β: 69.7° γ: 65.4°
R-values:
R R work R free
0.185 0.184 0.213
Expression system: Escherichia coli

Quick links

Citations

39 review citations

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Hardie DG. (2007)
38 more

15 mentions without citation

Unique carbohydrate binding platforms employed by the glucan phosphatases.
Emanuelle et al. (2016)
14 more