› 1a03

Solution NMR

THE THREE-DIMENSIONAL STRUCTURE OF CA2+-BOUND CALCYCLIN: IMPLICATIONS FOR CA2+-SIGNAL TRANSDUCTION BY S100 PROTEINS, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1a03/pdb
PDB entry 1a03 coloured by chain, ensemble of 20 models, front view.
PDB entry 1a03 coloured by chain, ensemble of 20 models, side view.
PDB entry 1a03 coloured by chain, ensemble of 20 models, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
The three-dimensional structure of Ca(2+)-bound calcyclin: implications for Ca(2+)-signal transduction by S100 proteins.
Sastry M, Ketchem RR, Crescenzi O, Weber C, Lubienski MJ, Hidaka H, Chazin WJ
Structure 6 223-31 (1998)
PMID: 9519412

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151802 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 90 amino acids
Theoretical weight: 10.17 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P30801 (Residues: 1-90; Coverage: 100%)
Gene name: S100A6
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Refinement method: METRIC MATRIX DISTANCE GEOMETRY, FOLLOWED BY RESTRAINED MOLECULAR DYNAMICS SIMULATED ANNEALING
Expression system: Escherichia coli

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Citations

16 review citations

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.
Donato R. (2001)
15 more

10 mentions without citation

Molecular dynamics simulations: advances and applications.
Hospital et al. (2015)
9 more