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EXONUCLEASE III FROM ESCHERICHIA COLI

Source organism: Escherichia coli K-12
Biochemical function: metal ion binding
Biological process: DNA damage response
Cellular component: cytosol

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EC 3.1.11.2: Exodeoxyribonuclease III

Reaction catalysed:
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
Systematic name:
-
Alternative Name(s):
  • E. coli exonuclease III
  • E.coli exonuclease III
  • Endoribonuclease III
  • Escherichia coli exonuclease III
  • Exonuclease III

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03372
Domain description: Endonuclease/Exonuclease/phosphatase family
Occurring in:
  1. Exodeoxyribonuclease III
The deposited structure of PDB entry 1ako contains 1 copy of Pfam domain PF03372 (Endonuclease/Exonuclease/phosphatase family) in Exodeoxyribonuclease III. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR020848
Domain description: AP endonuclease 1, conserved site
Occurring in:
  1. Exodeoxyribonuclease III
IPR037493
Domain description: Exodeoxyribonuclease III-like
Occurring in:
  1. Exodeoxyribonuclease III
IPR036691
Domain description: Endonuclease/exonuclease/phosphatase superfamily
Occurring in:
  1. Exodeoxyribonuclease III
IPR004808
Domain description: AP endonuclease 1
Occurring in:
  1. Exodeoxyribonuclease III
IPR020847
Domain description: AP endonuclease 1, binding site
Occurring in:
  1. Exodeoxyribonuclease III
IPR005135
Domain description: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. Exodeoxyribonuclease III

Structure domain

CATH CATH domain
3.60.10.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Deoxyribonuclease I; Chain A
Homology: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. Exodeoxyribonuclease III
The deposited structure of PDB entry 1ako contains 1 copy of CATH domain 3.60.10.10 (Deoxyribonuclease I; Chain A) in Exodeoxyribonuclease III. Showing 1 copy in chain A.
SCOP SCOP annotation
56220
Class: Alpha and beta proteins (a+b)
Fold: DNase I-like
Superfamily: DNase I-like
Occurring in:
  1. Exodeoxyribonuclease III
The deposited structure of PDB entry 1ako contains 1 copy of SCOP domain 56220 (DNase I-like) in Exodeoxyribonuclease III. Showing 1 copy in chain A.

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