› 1auq

X-ray diffraction
2.3Å resolution

A1 DOMAIN OF VON WILLEBRAND FACTOR

Released:
DOI: 10.2210/pdb1auq/pdb
PDB entry 1auq coloured by chain, front view.
PDB entry 1auq coloured by chain, side view.
PDB entry 1auq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib.
Emsley J, Cruz M, Handin R, Liddington R
J Biol Chem 273 10396-401 (1998)
PMID: 9553097

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
von Willebrand factor Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 23.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04275 (Residues: 1261-1468; Coverage: 8%)
Gene names: F8VWF, VWF
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

1 bound ligand:
Ligand CD 1 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P61
Unit cell:
a: 86.395Å b: 86.395Å c: 68.125Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.186 0.248
Expression system: Escherichia coli

Quick links

Citations

27 review citations

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.
Glickman et al. (2002)
26 more

42 mentions without citation

Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19.
Choudhary et al. (2021)
41 more