EC 3.4.21.5: Thrombin
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Systematic name:
-
Alternative Name(s):
- Activated blood-coagulation factor II
- Beta-thrombin
- Blood-coagulation factor IIa
- E thrombin
- Factor IIa
- Fibrinogenase
- Gamma-thrombin
- Thrombase
- Thrombin-C
- Thrombofort
- Topical
- Tropostasin
Protein families (Pfam)![The deposited structure of PDB entry 1awf contains 1 copy of Pfam domain PF09396 (Thrombin light chain) in Thrombin light chain. Showing 1 copy in chain A [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/1awf_1_L_Pfam_PF09396_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1awf</span> contains 1 copy of Pfam domain <span class='highlight'>PF09396 (Thrombin light chain)</span> in <span class='highlight'>Thrombin light chain</span>. Showing 1 copy in chain <span class='highlight'>A [auth L]</span>.")
![The deposited structure of PDB entry 1awf contains 1 copy of Pfam domain PF00089 (Trypsin) in Thrombin heavy chain. Showing 1 copy in chain B [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/1awf_2_H_Pfam_PF00089_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1awf</span> contains 1 copy of Pfam domain <span class='highlight'>PF00089 (Trypsin)</span> in <span class='highlight'>Thrombin heavy chain</span>. Showing 1 copy in chain <span class='highlight'>B [auth H]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 1awf contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Thrombin heavy chain. Showing 2 copies in chain B [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/1awf_2_H_CATH_2.40.10.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1awf</span> contains 2 copies of CATH domain <span class='highlight'>2.40.10.10 (Thrombin, subunit H)</span> in <span class='highlight'>Thrombin heavy chain</span>. Showing 2 copies in chain <span class='highlight'>B [auth H]</span>.")
SCOP annotation![The deposited structure of PDB entry 1awf contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Thrombin heavy chain. Showing 1 copy in chain B [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/1awf_2_H_SCOP_50514_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1awf</span> contains 1 copy of SCOP domain <span class='highlight'>50514 (Eukaryotic proteases)</span> in <span class='highlight'>Thrombin heavy chain</span>. Showing 1 copy in chain <span class='highlight'>B [auth H]</span>.")