› › Function and Biology

High resolution crystal structure of a MG2-dependent 5-aminolevulinic acid dehydratase

Source organism: Pseudomonas aeruginosa PAO1
Biochemical function: metal ion binding
Biological process: tetrapyrrole biosynthetic process
Cellular component: cytosol

Quick links

EC 4.2.1.24: Porphobilinogen synthase

Reaction catalysed:
2 5-aminolevulinate = porphobilinogen + 2 H(2)O
Systematic name:
5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
Alternative Name(s):
  • 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)
  • 5-levulinic acid dehydratase
  • Aminolevulinate dehydratase
  • Aminolevulinic dehydratase
  • Delta-aminolevulinate dehydratase
  • Delta-aminolevulinic acid dehydrase
  • Delta-aminolevulinic acid dehydratase
  • Delta-aminolevulinic dehydratase
  • HemB

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00490
Domain description: Delta-aminolevulinic acid dehydratase
Occurring in:
  1. Delta-aminolevulinic acid dehydratase
The deposited structure of PDB entry 1b4k contains 2 copies of Pfam domain PF00490 (Delta-aminolevulinic acid dehydratase) in Delta-aminolevulinic acid dehydratase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001731
Domain description: Delta-aminolevulinic acid dehydratase
Occurring in:
  1. Delta-aminolevulinic acid dehydratase
IPR030656
Domain description: Delta-aminolevulinic acid dehydratase, active site
Occurring in:
  1. Delta-aminolevulinic acid dehydratase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Delta-aminolevulinic acid dehydratase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Delta-aminolevulinic acid dehydratase
The deposited structure of PDB entry 1b4k contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Delta-aminolevulinic acid dehydratase. Showing 1 copy in chain A.
SCOP SCOP annotation
51594
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Occurring in:
  1. Delta-aminolevulinic acid dehydratase
The deposited structure of PDB entry 1b4k contains 2 copies of SCOP domain 51594 (5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)) in Delta-aminolevulinic acid dehydratase. Showing 1 copy in chain A.

Quick links