› 1bfs

X-ray diffraction
2.2Å resolution

STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE

Released:
DOI: 10.2210/pdb1bfs/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1bfs coloured by chain, front view.
PDB entry 1bfs coloured by chain, side view.
PDB entry 1bfs coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Huang DB, Huxford T, Chen YQ, Ghosh G
Structure 5 1427-36 (1997)
PMID: 9384558

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear factor NF-kappa-B p50 subunit Chain: A
Molecule details ›
Chain: A
Length: 106 amino acids
Theoretical weight: 12.26 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P25799 (Residues: 245-350; Coverage: 11%)
Gene name: Nfkb1
Sequence domains: Rel homology dimerisation domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
Spacegroup: P41212
Unit cell:
a: 62.33Å b: 62.33Å c: 65.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.183 0.287

Quick links

Citations

12 review citations

Transcriptional regulation via the NF-kappaB signaling module.
Hoffmann et al. (2006)
11 more

5 mentions without citation

Evolutionary plasticity of protein families: coupling between sequence and structure variation.
Panchenko et al. (2005)
4 more