› 1bre

X-ray diffraction
2Å resolution

IMMUNOGLOBULIN LIGHT CHAIN PROTEIN

Released:
DOI: 10.2210/pdb1bre/pdb
PDB entry 1bre coloured by chain, front view.
PDB entry 1bre coloured by chain, side view.
PDB entry 1bre coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tertiary structure of an amyloid immunoglobulin light chain protein: a proposed model for amyloid fibril formation.
Schormann N, Murrell JR, Liepnieks JJ, Benson MD
Proc Natl Acad Sci U S A 92 9490-4 (1995)
PMID: 7568160

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BENCE-JONES KAPPA I PROTEIN BRE Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 108 amino acids
Theoretical weight: 11.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 82.29Å b: 77.73Å c: 82.2Å
α: 90° β: 119.95° γ: 90°
R-values:
R R work R free
0.218 0.218 0.337
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Review: immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability.
Bellotti et al. (2000)
8 more

5 mentions without citation

Altered dimer interface decreases stability in an amyloidogenic protein.
Baden et al. (2008)
4 more