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Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.

Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G
Nat Struct Biol 6 574-81 (1999)
Cited: 60 times
EuropePMC logo PMID: 10360364

Abstract

Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.

Reviews - 1bwm mentioned but not cited (1)

  1. Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes. Armstrong KM, Piepenbrink KH, Baker BM. Biochem J 415 183-196 (2008)

Articles - 1bwm mentioned but not cited (1)



Reviews citing this publication (15)

  1. T cell antigen receptor recognition of antigen-presenting molecules. Rossjohn J, Gras S, Miles JJ, Turner SJ, Godfrey DI, McCluskey J. Annu Rev Immunol 33 169-200 (2015)
  2. Molecular interactions mediating T cell antigen recognition. van der Merwe PA, Davis SJ. Annu Rev Immunol 21 659-684 (2003)
  3. How T cells 'see' antigen. Krogsgaard M, Davis MM. Nat Immunol 6 239-245 (2005)
  4. The nature of molecular recognition by T cells. Davis SJ, Ikemizu S, Evans EJ, Fugger L, Bakker TR, van der Merwe PA. Nat Immunol 4 217-224 (2003)
  5. What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity? Housset D, Malissen B. Trends Immunol 24 429-437 (2003)
  6. Dynamics of cell surface molecules during T cell recognition. Davis MM, Krogsgaard M, Huppa JB, Sumen C, Purbhoo MA, Irvine DJ, Wu LC, Ehrlich L. Annu Rev Biochem 72 717-742 (2003)
  7. Cross-reactivity of T cells and its role in the immune system. Petrova G, Ferrante A, Gorski J. Crit Rev Immunol 32 349-372 (2012)
  8. Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism. Baker BM, Scott DR, Blevins SJ, Hawse WF. Immunol Rev 250 10-31 (2012)
  9. Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities. Armstrong KM, Insaidoo FK, Baker BM. J Mol Recognit 21 275-287 (2008)
  10. A role for "self" in T-cell activation. Krogsgaard M, Juang J, Davis MM. Semin Immunol 19 236-244 (2007)
  11. Self-reactive T cells and degeneracy of T cell recognition: evolving concepts-from sequence homology to shape mimicry and TCR flexibility. Maverakis E, van den Elzen P, Sercarz EE. J Autoimmun 16 201-209 (2001)
  12. Understanding the structural dynamics of TCR-pMHC complex interactions. Kass I, Buckle AM, Borg NA. Trends Immunol 35 604-612 (2014)
  13. TCR-MHC docking orientation: natural selection, or thymic selection? Collins EJ, Riddle DS. Immunol Res 41 267-294 (2008)
  14. Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy. Udyavar A, Geiger TL. Arch Immunol Ther Exp (Warsz) 58 335-346 (2010)
  15. A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis. Koukoulitsa C, Chontzopoulou E, Kiriakidi S, Tzakos AG, Mavromoustakos T. Brain Sci 10 E356 (2020)

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