1bz6 Citations

A steric mechanism for inhibition of CO binding to heme proteins.

Science 284 473-6 (1999)
Related entries: 1bzp, 1bzr

Cited: 133 times
EuropePMC logo PMID: 10205052

Abstract

The crystal structures of myoglobin in the deoxy- and carbon monoxide-ligated states at a resolution of 1.15 angstroms show that carbon monoxide binding at ambient temperatures requires concerted motions of the heme, the iron, and helices E and F for relief of steric inhibition. These steps constitute the main mechanism by which heme proteins lower the affinity of the heme group for the toxic ligand carbon monoxide.

Reviews - 1bz6 mentioned but not cited (1)

  1. Role of atomic contacts in vibrational energy transfer in myoglobin. Mizuno M, Mizutani Y. Biophys Rev 12 511-518 (2020)

Articles - 1bz6 mentioned but not cited (16)



Reviews citing this publication (8)

  1. Chemical shifts in amino acids, peptides, and proteins: from quantum chemistry to drug design. Oldfield E. Annu Rev Phys Chem 53 349-378 (2002)
  2. Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function. Adam SM, Wijeratne GB, Rogler PJ, Diaz DE, Quist DA, Liu JJ, Karlin KD. Chem Rev 118 10840-11022 (2018)
  3. Molecular aspects of embryonic hemoglobin function. Brittain T. Mol Aspects Med 23 293-342 (2002)
  4. Protein dynamics from time resolved UV Raman spectroscopy. Balakrishnan G, Weeks CL, Ibrahim M, Soldatova AV, Spiro TG. Curr Opin Struct Biol 18 623-629 (2008)
  5. Heme-based sensors: theoretical modeling of heme-ligand-protein interactions. Spiro TG, Jarzecki AA. Curr Opin Chem Biol 5 715-723 (2001)
  6. Quantum chemical studies of protein structure. Oldfield E. Philos Trans R Soc Lond B Biol Sci 360 1347-1361 (2005)
  7. Ambidentate H-bonding of NO and O2 in heme proteins. Spiro TG, Soldatova AV. J Inorg Biochem 115 204-210 (2012)
  8. Local structure and dynamics of hemeproteins by X-ray absorption near edge structure spectroscopy. Arcovito A, della Longa S. J Inorg Biochem 112 93-99 (2012)

Articles citing this publication (108)