› 1bzh

X-ray diffraction
2.1Å resolution

Cyclic peptide inhibitor of human PTP1B

Released:
DOI: 10.2210/pdb1bzh/pdb
PDB entry 1bzh coloured by chain, front view.
PDB entry 1bzh coloured by chain, side view.
PDB entry 1bzh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Groves MR, Yao ZJ, Roller PP, Burke TR, Barford D
Biochemistry 37 17773-83 (1998)
PMID: 9922143

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148260 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 1 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 34.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18031 (Residues: 1-298; Coverage: 69%)
Gene names: PTP1B, PTPN1
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR) Chain: I
Molecule details ›
Chain: I
Length: 7 amino acids
Theoretical weight: 1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
2 modified residues:
Ligand FLT 1 x FLT
Ligand AEA 1 x AEA

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21
Unit cell:
a: 39.69Å b: 86.82Å c: 52Å
α: 90° β: 96.91° γ: 90°
R-values:
R R work R free
0.196 0.196 0.262
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Protein tyrosine phosphatase 1B inhibitors for diabetes.
Johnson et al. (2002)
9 more

5 mentions without citation

A network pharmacology approach to understanding the mechanisms of action of traditional medicine: Bushenhuoxue formula for treatment of chronic kidney disease.
Shi et al. (2014)
4 more