› 1c1p

X-ray diffraction
1.37Å resolution

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES

Released:
DOI: 10.2210/pdb1c1p/pdb
PDB entry 1c1p coloured by chain, front view.
PDB entry 1c1p coloured by chain, side view.
PDB entry 1c1p coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Design of potent selective zinc-mediated serine protease inhibitors.
Katz BA, Clark JM, Finer-Moore JS, Jenkins TE, Johnson CR, Ross MJ, Luong C, Moore WR, Stroud RM
Nature 391 608-12 (1998)
PMID: 9468142

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease 1 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.32 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Gene names: PRSS1, TRP1, TRY1, TRYP1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

5 bound ligands:
Ligand CA 1 x CA
Ligand MG 1 x MG
Ligand SO4 2 x SO4
Ligand BAI 1 x BAI
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 54.86Å b: 54.86Å c: 109.79Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.178 0.192

Quick links

Citations

8 review citations

An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.
Pillaiyar et al. (2016)
7 more