› 1c2u

Solution NMR

SOLUTION STRUCTURE OF [ABU3,35]SHK12-28,17-32

Released:
DOI: 10.2210/pdb1c2u/pdb
PDB entry 1c2u coloured by chain, ensemble of 20 models, front view.
PDB entry 1c2u coloured by chain, ensemble of 20 models, side view.
PDB entry 1c2u coloured by chain, ensemble of 20 models, top view.
Source organism: Stichodactyla helianthus
Primary publication:
Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin.
Pennington MW, Lanigan MD, Kalman K, Mahnir VM, Rauer H, McVaugh CT, Behm D, Donaldson D, Chandy KG, Kem WR, Norton RS
Biochemistry 38 14549-58 (1999)
PMID: 10545177

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kappa-stichotoxin-She3a Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 3.97 KDa
Source organism: Stichodactyla helianthus
Expression system: Not provided
UniProt:
  • Canonical: P29187 (Residues: 1-35; Coverage: 100%)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ABA 2 x ABA

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Refinement method: THE STRUCTURES WERE REFINED USING DISTANCE GEOMETRY, SIMULATED ANNEALING AND MOLECULAR DYNAMICS
Expression system: Not provided

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Citations

4 review citations

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases.
Chi et al. (2012)
3 more