1c3d › Citations

X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2.

Nagar B, Jones RG, Diefenbach RJ, Isenman DE, Rini JM
Science 280 1277-81 (1998)
Cited: 137 times
EuropePMC logo PMID: 9596584

Abstract

Activation and covalent attachment of complement component C3 to pathogens is the key step in complement-mediated host defense. Additionally, the antigen-bound C3d fragment interacts with complement receptor 2 (CR2; also known as CD21) on B cells and thereby contributes to the initiation of an acquired humoral response. The x-ray crystal structure of human C3d solved at 2.0 angstroms resolution reveals an alpha-alpha barrel with the residues responsible for thioester formation and covalent attachment at one end and an acidic pocket at the other. The structure supports a model whereby the transition of native C3 to its functionally active state involves the disruption of a complementary domain interface and provides insight into the basis for the interaction between C3d and CR2.

Reviews - 1c3d mentioned but not cited (6)

  1. Novel mechanisms and functions of complement. Hajishengallis G, Reis ES, Mastellos DC, Ricklin D, Lambris JD. Nat Immunol 18 1288-1298 (2017)
  2. Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense. Ricklin D, Reis ES, Mastellos DC, Gros P, Lambris JD. Immunol Rev 274 33-58 (2016)
  3. Therapeutic control of complement activation at the level of the central component C3. Ricklin D, Lambris JD. Immunobiology 221 740-746 (2016)
  4. Complement component C3: A structural perspective and potential therapeutic implications. Geisbrecht BV, Lambris JD, Gros P. Semin Immunol 59 101627 (2022)
  5. Overview of protein structural and functional folds. Sun PD, Foster CE, Boyington JC. Curr Protoc Protein Sci Chapter 17 Unit 17.1 (2004)
  6. Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens' Infectivity? Hardy E, Sarker H, Fernandez-Patron C. Cells 12 1699 (2023)

Articles - 1c3d mentioned but not cited (31)

  1. A graph-theory algorithm for rapid protein side-chain prediction. Canutescu AA, Shelenkov AA, Dunbrack RL. Protein Sci 12 2001-2014 (2003)
  2. Protein-protein docking benchmark version 4.0. Hwang H, Vreven T, Janin J, Weng Z. Proteins 78 3111-3114 (2010)
  3. HawkDock: a web server to predict and analyze the protein-protein complex based on computational docking and MM/GBSA. Weng G, Wang E, Wang Z, Liu H, Zhu F, Li D, Hou T. Nucleic Acids Res 47 W322-W330 (2019)
  4. Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2. Vreven T, Moal IH, Vangone A, Pierce BG, Kastritis PL, Torchala M, Chaleil R, Jiménez-García B, Bates PA, Fernandez-Recio J, Bonvin AM, Weng Z. J Mol Biol 427 3031-3041 (2015)
  5. Protein-protein docking benchmark version 3.0. Hwang H, Pierce B, Mintseris J, Janin J, Weng Z. Proteins 73 705-709 (2008)
  6. Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. Jokiranta TS, Jaakola VP, Lehtinen MJ, Pärepalo M, Meri S, Goldman A. EMBO J 25 1784-1794 (2006)
  7. Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3. Bajic G, Yatime L, Sim RB, Vorup-Jensen T, Andersen GR. Proc Natl Acad Sci U S A 110 16426-16431 (2013)
  8. Microbes bind complement inhibitor factor H via a common site. Meri T, Amdahl H, Lehtinen MJ, Hyvärinen S, McDowell JV, Bhattacharjee A, Meri S, Marconi R, Goldman A, Jokiranta TS. PLoS Pathog 9 e1003308 (2013)
  9. Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome. Lehtinen MJ, Rops AL, Isenman DE, van der Vlag J, Jokiranta TS. J Biol Chem 284 15650-15658 (2009)
  10. New Strategies and Challenges in Lung Proteomics and Metabolomics. An Official American Thoracic Society Workshop Report. Bowler RP, Wendt CH, Fessler MB, Foster MW, Kelly RS, Lasky-Su J, Rogers AJ, Stringer KA, Winston BW, American Thoracic Society Workgroup on Metabolomics and Proteomics. Ann Am Thorac Soc 14 1721-1743 (2017)
  11. A revised mechanism for the activation of complement C3 to C3b: a molecular explanation of a disease-associated polymorphism. Rodriguez E, Nan R, Li K, Gor J, Perkins SJ. J Biol Chem 290 2334-2350 (2015)
  12. Protein-protein docking by fast generalized Fourier transforms on 5D rotational manifolds. Padhorny D, Kazennov A, Zerbe BS, Porter KA, Xia B, Mottarella SE, Kholodov Y, Ritchie DW, Vajda S, Kozakov D. Proc Natl Acad Sci U S A 113 E4286-93 (2016)
  13. Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. Nan R, Tetchner S, Rodriguez E, Pao PJ, Gor J, Lengyel I, Perkins SJ. J Biol Chem 288 19197-19210 (2013)
  14. Predicting protein function from structure: unique structural features of proteases. Stawiski EW, Baucom AE, Lohr SC, Gregoret LM. Proc Natl Acad Sci U S A 97 3954-3958 (2000)
  15. Protein-protein binding site identification by enumerating the configurations. Guo F, Li SC, Wang L, Zhu D. BMC Bioinformatics 13 158 (2012)
  16. Binding interface prediction by combining protein-protein docking results. Hwang H, Vreven T, Weng Z. Proteins 82 57-66 (2014)
  17. Application of Enhanced Sampling Monte Carlo Methods for High-Resolution Protein-Protein Docking in Rosetta. Zhang Z, Schindler CE, Lange OF, Zacharias M. PLoS One 10 e0125941 (2015)
  18. F2Dock: fast Fourier protein-protein docking. Bajaj C, Chowdhury R, Siddavanahalli V. IEEE/ACM Trans Comput Biol Bioinform 8 45-58 (2011)
  19. The two sides of complement C3d: evolution of electrostatics in a link between innate and adaptive immunity. Kieslich CA, Morikis D. PLoS Comput Biol 8 e1002840 (2012)
  20. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. PLoS One 11 e0166200 (2016)
  21. Structural Implications for the Formation and Function of the Complement Effector Protein iC3b. Papanastasiou M, Koutsogiannaki S, Sarigiannis Y, Geisbrecht BV, Ricklin D, Lambris JD. J Immunol 198 3326-3335 (2017)
  22. A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d. Clark EA, Crennell S, Upadhyay A, Zozulya AV, Mackay JD, Svergun DI, Bagby S, van den Elsen JM. Mol Immunol 48 452-462 (2011)
  23. Conformational switch-defective X174 internal scaffolding proteins kinetically trap assembly intermediates before procapsid formation. Gordon EB, Knuff CJ, Fane BA. J Virol 86 9911-9918 (2012)
  24. Identification of functional similarities between proteins using directed evolution. Christ D, Winter G. Proc Natl Acad Sci U S A 100 13202-13206 (2003)
  25. The structure and function of thioester-containing proteins in arthropods. Williams M, Baxter R. Biophys Rev 6 261-272 (2014)
  26. Comparison of tertiary structures of proteins in protein-protein complexes with unbound forms suggests prevalence of allostery in signalling proteins. Swapna LS, Mahajan S, de Brevern AG, Srinivasan N. BMC Struct Biol 12 6 (2012)
  27. Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor. Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M. Nat Commun 13 5085 (2022)
  28. Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi. Kolodziejczyk R, Mikula KM, Kotila T, Postis VLG, Jokiranta TS, Goldman A, Meri T. PLoS One 12 e0188127 (2017)
  29. Effects of an early conformational switch defect during ϕX174 morphogenesis are belatedly manifested late in the assembly pathway. Gordon EB, Fane BA. J Virol 87 2518-2525 (2013)
  30. Insights Into the Structure-Function Relationships of Dimeric C3d Fragments. Wahid AA, Dunphy RW, Macpherson A, Gibson BG, Kulik L, Whale K, Back C, Hallam TM, Alkhawaja B, Martin RL, Meschede I, Laabei M, Lawson ADG, Holers VM, Watts AG, Crennell SJ, Harris CL, Marchbank KJ, van den Elsen JMH. Front Immunol 12 714055 (2021)
  31. A Coarse-Grained Methodology Identifies Intrinsic Mechanisms That Dissociate Interacting Protein Pairs. Abdizadeh H, Jalalypour F, Atilgan AR, Atilgan C. Front Mol Biosci 7 210 (2020)


Reviews citing this publication (22)

  1. Complement and its role in innate and adaptive immune responses. Dunkelberger JR, Song WC. Cell Res 20 34-50 (2010)
  2. Complement-targeted therapeutics. Ricklin D, Lambris JD. Nat Biotechnol 25 1265-1275 (2007)
  3. Regulation of humoral immunity by complement. Carroll MC, Isenman DE. Immunity 37 199-207 (2012)
  4. Complement driven by conformational changes. Gros P, Milder FJ, Janssen BJ. Nat Rev Immunol 8 48-58 (2008)
  5. Human complement regulators: a major target for pathogenic microorganisms. Lindahl G, Sjöbring U, Johnsson E. Curr Opin Immunol 12 44-51 (2000)
  6. Evolution and diversity of the complement system of poikilothermic vertebrates. Sunyer JO, Lambris JD. Immunol Rev 166 39-57 (1998)
  7. The phylogeny and evolution of the thioester bond-containing proteins C3, C4 and alpha 2-macroglobulin. Dodds AW, Law SK. Immunol Rev 166 15-26 (1998)
  8. Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity. Toapanta FR, Ross TM. Immunol Res 36 197-210 (2006)
  9. Phylogenetic aspects of the complement system. Zarkadis IK, Mastellos D, Lambris JD. Dev Comp Immunol 25 745-762 (2001)
  10. Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1. Hourcade D, Liszewski MK, Krych-Goldberg M, Atkinson JP. Immunopharmacology 49 103-116 (2000)
  11. Structural insights into the central complement component C3. Janssen BJ, Gros P. Mol Immunol 44 3-10 (2007)
  12. Complement: structure, functions, evolution, and viral molecular mimicry. Mastellos D, Morikis D, Isaacs SN, Holland MC, Strey CW, Lambris JD. Immunol Res 27 367-386 (2003)
  13. Expansion of genes encoding complement components in bony fish: biological implications of the complement diversity. Nakao M, Mutsuro J, Nakahara M, Kato Y, Yano T. Dev Comp Immunol 27 749-762 (2003)
  14. Deciphering complement mechanisms: the contributions of structural biology. Arlaud GJ, Barlow PN, Gaboriaud C, Gros P, Narayana SV. Mol Immunol 44 3809-3822 (2007)
  15. Complement receptor type two (CR2,CR21): a target for influencing the humoral immune response and antigen-trapping. Prodinger WM. Immunol Res 20 187-194 (1999)
  16. Do follicular dendritic cells regulate lupus-specific B cells? Heesters BA, Das A, Chatterjee P, Carroll MC. Mol Immunol 62 283-288 (2014)
  17. Putting the structure into complement. Lea SM, Johnson S. Immunobiology 217 1117-1121 (2012)
  18. How novel structures inform understanding of complement function. de Jorge EG, Yebenes H, Serna M, Tortajada A, Llorca O, de Córdoba SR. Semin Immunopathol 40 3-14 (2018)
  19. Was it there all the time? Bennett M, Leanderson T. Scand J Immunol 57 499-505 (2003)
  20. Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer. Gadwa J, Karam SD. Int J Radiat Oncol Biol Phys 108 46-55 (2020)
  21. Molecular structure and expression of anthropic, ovine, and murine forms of complement receptor type 2. Liu D, Zhu JY, Niu ZX. Clin Vaccine Immunol 15 901-910 (2008)
  22. Complement factor H: a novel innate immune checkpoint in cancer immunotherapy. Saxena R, Gottlin EB, Campa MJ, Bushey RT, Guo J, Patz EF, He YW. Front Cell Dev Biol 12 1302490 (2024)

Articles citing this publication (78)

  1. Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae. Levashina EA, Moita LF, Blandin S, Vriend G, Lagueux M, Kafatos FC. Cell 104 709-718 (2001)
  2. Structures of complement component C3 provide insights into the function and evolution of immunity. Janssen BJ, Huizinga EG, Raaijmakers HC, Roos A, Daha MR, Nilsson-Ekdahl K, Nilsson B, Gros P. Nature 437 505-511 (2005)
  3. Structure of C3b reveals conformational changes that underlie complement activity. Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P. Nature 444 213-216 (2006)
  4. Structural basis for engagement by complement factor H of C3b on a self surface. Morgan HP, Schmidt CQ, Guariento M, Blaum BS, Gillespie D, Herbert AP, Kavanagh D, Mertens HD, Svergun DI, Johansson CM, Uhrín D, Barlow PN, Hannan JP. Nat Struct Mol Biol 18 463-470 (2011)
  5. Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Kajander T, Lehtinen MJ, Hyvärinen S, Bhattacharjee A, Leung E, Isenman DE, Meri S, Goldman A, Jokiranta TS. Proc Natl Acad Sci U S A 108 2897-2902 (2011)
  6. A structural basis for complement inhibition by Staphylococcus aureus. Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV. Nat Immunol 8 430-437 (2007)
  7. Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus. Burman JD, Leung E, Atkins KL, O'Seaghdha MN, Lango L, Bernadó P, Bagby S, Svergun DI, Foster TJ, Isenman DE, van den Elsen JM. J Biol Chem 283 17579-17593 (2008)
  8. Structural transitions of complement component C3 and its activation products. Nishida N, Walz T, Springer TA. Proc Natl Acad Sci U S A 103 19737-19742 (2006)
  9. Complement C3b/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H. Hellwage J, Jokiranta TS, Friese MA, Wolk TU, Kampen E, Zipfel PF, Meri S. J Immunol 169 6935-6944 (2002)
  10. Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Serruto D, Rappuoli R, Scarselli M, Gros P, van Strijp JA. Nat Rev Microbiol 8 393-399 (2010)
  11. RETRACTED: Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans. Murthy KH, Smith SA, Ganesh VK, Judge KW, Mullin N, Barlow PN, Ogata CM, Kotwal GJ. Cell 104 301-311 (2001)
  12. Structure of the Epstein-Barr virus major envelope glycoprotein. Szakonyi G, Klein MG, Hannan JP, Young KA, Ma RZ, Asokan R, Holers VM, Chen XS. Nat Struct Mol Biol 13 996-1001 (2006)
  13. Crystal structure of a class I alpha1,2-mannosidase involved in N-glycan processing and endoplasmic reticulum quality control. Vallée F, Lipari F, Yip P, Sleno B, Herscovics A, Howell PL. EMBO J 19 581-588 (2000)
  14. Characterization of a C3-like cDNA in a coral: phylogenetic implications. Dishaw LJ, Smith SL, Bigger CH. Immunogenetics 57 535-548 (2005)
  15. Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. Zhang H, Seabra MC, Deisenhofer J. Structure 8 241-251 (2000)
  16. Complement receptor type 1 (CD35) mediates inhibitory signals in human B lymphocytes. Józsi M, Prechl J, Bajtay Z, Erdei A. J Immunol 168 2782-2788 (2002)
  17. Structural basis for conserved complement factor-like function in the antimalarial protein TEP1. Baxter RH, Chang CI, Chelliah Y, Blandin S, Levashina EA, Deisenhofer J. Proc Natl Acad Sci U S A 104 11615-11620 (2007)
  18. A crystal structure of the complex between human complement receptor 2 and its ligand C3d. van den Elsen JM, Isenman DE. Science 332 608-611 (2011)
  19. Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study. Gilbert HE, Eaton JT, Hannan JP, Holers VM, Perkins SJ. J Mol Biol 346 859-873 (2005)
  20. The structure of complement C3b provides insights into complement activation and regulation. Abdul Ajees A, Gunasekaran K, Volanakis JE, Narayana SV, Kotwal GJ, Murthy HM. Nature 444 221-225 (2006)
  21. Cloning and structure of three rainbow trout C3 molecules: a plausible explanation for their functional diversity. Zarkadis IK, Sarrias MR, Sfyroera G, Sunyer JO, Lambris JD. Dev Comp Immunol 25 11-24 (2001)
  22. The structure of bovine complement component 3 reveals the basis for thioester function. Fredslund F, Jenner L, Husted LB, Nyborg J, Andersen GR, Sottrup-Jensen L. J Mol Biol 361 115-127 (2006)
  23. Dissociation of HIV-1 from follicular dendritic cells during HAART: mathematical analysis. Hlavacek WS, Wofsy C, Perelson AS. Proc Natl Acad Sci U S A 96 14681-14686 (1999)
  24. Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2. Ricklin D, Ricklin-Lichtsteiner SK, Markiewski MM, Geisbrecht BV, Lambris JD. J Immunol 181 7463-7467 (2008)
  25. Progress and Trends in Complement Therapeutics. Ricklin D, Lambris JD. Adv Exp Med Biol 735 1-22 (2013)
  26. The structure of OMCI, a novel lipocalin inhibitor of the complement system. Roversi P, Lissina O, Johnson S, Ahmat N, Paesen GC, Ploss K, Boland W, Nunn MA, Lea SM. J Mol Biol 369 784-793 (2007)
  27. Structure-guided identification of C3d residues essential for its binding to complement receptor 2 (CD21). Clemenza L, Isenman DE. J Immunol 165 3839-3848 (2000)
  28. X-ray crystal structure of the C4d fragment of human complement component C4. van den Elsen JM, Martin A, Wong V, Clemenza L, Rose DR, Isenman DE. J Mol Biol 322 1103-1115 (2002)
  29. Identification of residues within the 727-767 segment of human complement component C3 important for its interaction with factor H and with complement receptor 1 (CR1, CD35). Oran AE, Isenman DE. J Biol Chem 274 5120-5130 (1999)
  30. Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d. Hannan JP, Young KA, Guthridge JM, Asokan R, Szakonyi G, Chen XS, Holers VM. J Mol Biol 346 845-858 (2005)
  31. Molecular dynamics simulations of wild type and mutants of human complement receptor 2 complexed with C3d. Wan H, Hu JP, Tian XH, Chang S. Phys Chem Chem Phys 15 1241-1251 (2013)
  32. Identification and molecular characterization of a complement C3 molecule in a lophotrochozoan, the Hawaiian bobtail squid Euprymna scolopes. Castillo MG, Goodson MS, McFall-Ngai M. Dev Comp Immunol 33 69-76 (2009)
  33. The electrostatic nature of C3d-complement receptor 2 association. Morikis D, Lambris JD. J Immunol 172 7537-7547 (2004)
  34. Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure. Isenman DE, Leung E, Mackay JD, Bagby S, van den Elsen JM. J Immunol 184 1946-1955 (2010)
  35. Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3. Doan N, Gettins PG. Biochem J 407 23-30 (2007)
  36. Solution structure of the complex formed between human complement C3d and full-length complement receptor type 2. Li K, Okemefuna AI, Gor J, Hannan JP, Asokan R, Holers VM, Perkins SJ. J Mol Biol 384 137-150 (2008)
  37. Immunophysical properties and prediction of activities for vaccinia virus complement control protein and smallpox inhibitor of complement enzymes using molecular dynamics and electrostatics. Zhang L, Morikis D. Biophys J 90 3106-3119 (2006)
  38. Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d. Haspel N, Ricklin D, Geisbrecht BV, Kavraki LE, Lambris JD. Protein Sci 17 1894-1906 (2008)
  39. Immunophysical exploration of C3d-CR2(CCP1-2) interaction using molecular dynamics and electrostatics. Zhang L, Mallik B, Morikis D. J Mol Biol 369 567-583 (2007)
  40. A new apoptotic pathway for the complement factor B-derived fragment Bb. Uwai M, Terui Y, Mishima Y, Tomizuka H, Ikeda M, Itoh T, Mori M, Ueda M, Inoue R, Yamada M, Hayasawa H, Horiuchi T, Niho Y, Matsumoto M, Ishizaka Y, Ikeda K, Ozawa K, Hatake K. J Cell Physiol 185 280-292 (2000)
  41. Functional insights from the structure of the multifunctional C345C domain of C5 of complement. Bramham J, Thai CT, Soares DC, Uhrín D, Ogata RT, Barlow PN. J Biol Chem 280 10636-10645 (2005)
  42. Solvent accessibility of native and hydrolyzed human complement protein 3 analyzed by hydrogen/deuterium exchange and mass spectrometry. Winters MS, Spellman DS, Lambris JD. J Immunol 174 3469-3474 (2005)
  43. alpha-Macroglobulins are present in some gram-negative bacteria: characterization of the alpha2-macroglobulin from Escherichia coli. Doan N, Gettins PG. J Biol Chem 283 28747-28756 (2008)
  44. Molecular isoforms of cobra venom factor-like proteins in the venom of Austrelaps superbus. Rehana S, Manjunatha Kini R. Toxicon 50 32-52 (2007)
  45. The covalent interaction of C3 with IgG immune complexes. Vivanco F, Muñoz E, Vidarte L, Pastor C. Mol Immunol 36 843-852 (1999)
  46. Automated computational framework for the analysis of electrostatic similarities of proteins. Kieslich CA, Morikis D, Yang J, Gunopulos D. Biotechnol Prog 27 316-325 (2011)
  47. Ig-like transcript 4 as a cellular receptor for soluble complement fragment C4d. Hofer J, Forster F, Isenman DE, Wahrmann M, Leitner J, Hölzl MA, Kovarik JJ, Stockinger H, Böhmig GA, Steinberger P, Zlabinger GJ. FASEB J 30 1492-1503 (2016)
  48. Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network. Martínez-Riaño A, Wang S, Boeing S, Minoughan S, Casal A, Spillane KM, Ludewig B, Tolar P. Nat Immunol 24 1281-1294 (2023)
  49. Multimeric interactions between complement factor H and its C3d ligand provide new insight on complement regulation. Okemefuna AI, Li K, Nan R, Ormsby RJ, Sadlon T, Gordon DL, Perkins SJ. J Mol Biol 391 119-135 (2009)
  50. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. J Immunol 200 316-326 (2018)
  51. Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry. Chen H, Schuster MC, Sfyroera G, Geisbrecht BV, Lambris JD. J Am Soc Mass Spectrom 19 55-65 (2008)
  52. Coarse-Grained Conformational Sampling of Protein Structure Improves the Fit to Experimental Hydrogen-Exchange Data. Devaurs D, Antunes DA, Papanastasiou M, Moll M, Ricklin D, Lambris JD, Kavraki LE. Front Mol Biosci 4 13 (2017)
  53. A theoretical view of the C3d:CR2 binding controversy. Mohan RR, Gorham RD, Morikis D. Mol Immunol 64 112-122 (2015)
  54. Spontaneous formation of heterogeneous patches on polymer-lipid core-shell particle surfaces during self-assembly. Salvador-Morales C, Valencia PM, Gao W, Karnik R, Farokhzad OC. Small 9 511-517 (2013)
  55. Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics. Garcia BL, Skaff DA, Chatterjee A, Hanning A, Walker JK, Wyckoff GJ, Geisbrecht BV. J Immunol 198 3705-3718 (2017)
  56. Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy. Gilbert HE, Aslam M, Guthridge JM, Holers VM, Perkins SJ. J Mol Biol 356 397-412 (2006)
  57. Neuropilin-1 Acts as a Receptor for Complement Split Products. Battin C, De Sousa Linhares A, Paster W, Isenman DE, Wahrmann M, Leitner J, Zlabinger GJ, Steinberger P, Hofer J. Front Immunol 10 2209 (2019)
  58. A complement C3 fragment equivalent to mammalian C3d from the common carp (Cyprinus carpio): generation in serum after activation of the alternative pathway and detection of its receptor on the lymphocyte surface. Nakao M, Miura C, Itoh S, Nakahara M, Okumura K, Mutsuro J, Yano T. Fish Shellfish Immunol 16 139-149 (2004)
  59. Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant. Yang Y, Back CR, Gräwert MA, Wahid AA, Denton H, Kildani R, Paulin J, Wörner K, Kaiser W, Svergun DI, Sartbaeva A, Watts AG, Marchbank KJ, van den Elsen JMH. Front Immunol 9 3139 (2018)
  60. Description of local and global shape properties of protein helices. Guo Z, Kraka E, Cremer D. J Mol Model 19 2901-2911 (2013)
  61. Mucosal type mast cells express complement receptor type 2 (CD21). Andrásfalvy M, Prechl J, Hardy T, Erdei A, Bajtay Z. Immunol Lett 82 29-34 (2002)
  62. Congress Into the third century of complement research. Morgan BP, Daha M, Meri S, Nicholson-Weller A. Immunol Today 21 603-605 (2000)
  63. C3d adjuvant activity is reduced by altering residues involved in the electronegative binding of C3d to CR2. Toapanta FR, DeAlmeida DR, Dunn MD, Ross TM. Immunol Lett 129 32-38 (2010)
  64. Topical Trabodenoson Is Neuroprotective in a Rodent Model of Anterior Ischemic Optic Neuropathy (rNAION). Guo Y, Mehrabian Z, Johnson MA, Albers DS, Rich CC, Baumgartner RA, Bernstein SL. Transl Vis Sci Technol 8 47 (2019)
  65. C3b and factor H: key components of the complement system. Jokiranta TS. Expert Rev Clin Immunol 2 775-786 (2006)
  66. Evolution of the complement system C3 gene in Antarctic teleosts. Melillo D, Varriale S, Giacomelli S, Natale L, Bargelloni L, Oreste U, Pinto MR, Coscia MR. Mol Immunol 66 299-309 (2015)
  67. Properties that rank protein:protein docking poses with high accuracy. Simões ICM, Coimbra JTS, Neves RPP, Costa IPD, Ramos MJ, Fernandes PA. Phys Chem Chem Phys 20 20927-20942 (2018)
  68. The Streptococcus agalactiae complement interfering protein combines multiple complement-inhibitory mechanisms by interacting with both C4 and C3 ligands. Giussani S, Pietrocola G, Donnarumma D, Norais N, Speziale P, Fabbrini M, Margarit I. FASEB J 33 4448-4457 (2019)
  69. Two divergent isotypes of the fourth complement component from a bony fish, the common carp (Cyprinus carpio). Mutsuro J, Tanaka N, Kato Y, Dodds AW, Yano T, Nakao M. J Immunol 175 4508-4517 (2005)
  70. Contribution of Chinese Pekin duck complement component C3d-P29 repeats to enhancement of Th2-biased immune responses against NDV F gene induced by DNA immunization. Liu D, Wang J, Niu ZX. Immunopharmacol Immunotoxicol 32 297-306 (2010)
  71. Molecular cloning of Gibel carp (Carassius auratus gibelio) complement component C3 and its expression profile after Cyprinid herpesvirus 2 infection. Fan Y, Zhang X, Zhou Y, Jiang N, Liu W, Zeng L. J Vet Med Sci 82 47-55 (2020)
  72. Native State of Complement Protein C3d Analysed via Hydrogen Exchange and Conformational Sampling. Devaurs D, Papanastasiou M, Antunes DA, Abella JR, Moll M, Ricklin D, Lambris JD, Kavraki LE. Int J Comput Biol Drug Des 11 90-113 (2018)
  73. Staphylococcal Complement Evasion Protein Sbi Stabilises C3d Dimers by Inducing an N-Terminal Helix Swap. Dunphy RW, Wahid AA, Back CR, Martin RL, Watts AG, Dodson CA, Crennell SJ, van den Elsen JMH. Front Immunol 13 892234 (2022)
  74. Comment Structural biology: origins of chemical biodefence. Liddington R, Bankston L. Nature 437 484-485 (2005)
  75. Complement C3 isoforms in Austrelaps superbus. Rehana S, Kini RM. Toxicon 51 864-881 (2008)
  76. Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response. Bale S, Yang L, Alirezaei M, Wilson R, Ota T, Doyle ED, Cottrell CA, Guenaga J, Tran K, Li W, Stamatatos L, Nemazee D, Ward AB, Wyatt RT. Front Immunol 14 1180959 (2023)
  77. Antibacterial Properties and Potential Mechanism of Serum from Chinese Alligator. Hu MY, Chen YW, Chai ZF, Wang YZ, Lin JQ, Fang SG. Microorganisms 10 2210 (2022)
  78. The molecular mechanism of pH-regulating C3d-CR2 interactions: Insights from molecular dynamics simulation. Zhang Y, Guo J, Ning L, Tian J, Yao X, Liu H. Chem Biol Drug Des 93 628-637 (2019)


Quick links